| Host: | Rabbit |
| Applications: | WB/IHC/IF/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Creb-Binding Protein is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | PT0526R |
| Conjugation: | Unconjugated |
| Isotype: | IgGk |
| Formulation: | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification: | Protein A |
| Dilution Range: | IHC 1:200-1:1000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000IP 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Function | Acetylates histones, giving a specific tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Acetylates PCNA.acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region. Acetylates DDX21, thereby inhibiting DDX21 helicase activity. Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as lactoyl-CoA, and is able to mediate protein lactylation. Catalyzes lactylation of MRE11 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway. |
| Protein Name | Creb-Binding ProteinHistone Lysine Acetyltransferase CrebbpProtein Lactyltransferas CrebbpProtein-Lysine Acetyltransferase Crebbp |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1912408Reactome: R-HSA-1989781Reactome: R-HSA-201722Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3134973Reactome: R-HSA-3214847Reactome: R-HSA-3371568Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-5617472Reactome: R-HSA-5621575Reactome: R-HSA-6803204Reactome: R-HSA-8866907Reactome: R-HSA-8939246Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9018519Reactome: R-HSA-918233Reactome: R-HSA-933541Reactome: R-HSA-9614657Reactome: R-HSA-9617629Reactome: R-HSA-9705671Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9759194Reactome: R-HSA-9768919Reactome: R-HSA-9793380Reactome: R-HSA-9818026Reactome: R-HSA-9818027Reactome: R-HSA-9818028Reactome: R-HSA-9818030Reactome: R-HSA-9818032Reactome: R-HSA-9818035Reactome: R-HSA-9818749Reactome: R-HSA-9819196Reactome: R-HSA-9833109Reactome: R-HSA-9841922Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusRecruited To Nuclear Bodies By Ss18l1/CrestIn The Presence Of Alx1 Relocalizes From The Cytoplasm To The NucleusRelocalizes From The Nucleus To The Cytoplasm Following Uv Cell Damage |
| Alternative Antibody Names | Anti-Creb-Binding Protein antibodyAnti-Histone Lysine Acetyltransferase Crebbp antibodyAnti-Protein Lactyltransferas Crebbp antibodyAnti-Protein-Lysine Acetyltransferase Crebbp antibodyAnti-CREBBP antibodyAnti-CBP antibody |
Information sourced from Uniprot.org
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