| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cyclic AMP-responsive element-binding protein 3-like protein 4 (200-280 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CREB3L4 |
| Gene ID: | 148327 |
| Uniprot ID: | CR3L4_HUMAN |
| Immunogen Region: | 200-280 aa |
| Specificity: | CR3L4 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 200-280 |
| Post Translational Modifications | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-TGTACGTGAGT-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 Camp-Responsive Element-Binding Protein 3-Like Protein 4 Androgen-Induced Basic Leucine Zipper Protein Aibzip Attaching To Cre-Like 1 Atce1 Cyclic Amp-Responsive Element-Binding Protein 4 Creb-4 Camp-Responsive Element-Binding Protein 4 Transcript Induced In Spermiogenesis Protein 40 Tisp40 Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein Golgi Apparatus Membrane May Also Be Located In Golgi Apparatus Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4: Nucleus Under Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibody Anti-Camp-Responsive Element-Binding Protein 3-Like Protein 4 antibody Anti-Androgen-Induced Basic Leucine Zipper Protein antibody Anti-Aibzip antibody Anti-Attaching To Cre-Like 1 antibody Anti-Atce1 antibody Anti-Cyclic Amp-Responsive Element-Binding Protein 4 antibody Anti-Creb-4 antibody Anti-Camp-Responsive Element-Binding Protein 4 antibody Anti-Transcript Induced In Spermiogenesis Protein 40 antibody Anti-Tisp40 antibody Anti-Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibody Anti-CREB3L4 antibody Anti-AIBZIP antibody Anti-CREB4 antibody Anti-JAL antibody |
Information sourced from Uniprot.org