| Post Translational Modifications | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-TGTACGTGAGT-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4Camp-Responsive Element-Binding Protein 3-Like Protein 4Androgen-Induced Basic Leucine Zipper ProteinAibzipAttaching To Cre-Like 1Atce1Cyclic Amp-Responsive Element-Binding Protein 4Creb-4Camp-Responsive Element-Binding Protein 4Transcript Induced In Spermiogenesis Protein 40Tisp40Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneMay Also Be Located In Golgi ApparatusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Androgen-Induced Basic Leucine Zipper Protein antibodyAnti-Aibzip antibodyAnti-Attaching To Cre-Like 1 antibodyAnti-Atce1 antibodyAnti-Cyclic Amp-Responsive Element-Binding Protein 4 antibodyAnti-Creb-4 antibodyAnti-Camp-Responsive Element-Binding Protein 4 antibodyAnti-Transcript Induced In Spermiogenesis Protein 40 antibodyAnti-Tisp40 antibodyAnti-Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-CREB3L4 antibodyAnti-AIBZIP antibodyAnti-CREB4 antibodyAnti-JAL antibody |
Information sourced from Uniprot.org
