| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-CREB1 (96-109) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 45kDa band observed in nuclear lysates of cell lines Jurkat and NIH3T3 (calculated MW of 36.7kDa according to NP_604391.1). This molecular weight is routinely observed by other |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CREB1 |
| Gene ID: | 1385 |
| Uniprot ID: | CREB1_HUMAN |
| Immunogen Region: | 96-109 |
| Accession Number: | NP_004370.1; NP_604391.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_004370.1; NP_604391.1). |
| Immunogen Sequence: | DSQESVDSVTDSQK |
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 1Creb-1Camp-Responsive Element-Binding Protein 1 |
| Database Links | Reactome: R-HSA-111931 P16220-1Reactome: R-HSA-111932 P16220-1Reactome: R-HSA-198693 P16220-1Reactome: R-HSA-199920 P16220-1Reactome: R-HSA-2151201 P16220-1Reactome: R-HSA-2197563 P16220-1Reactome: R-HSA-375165 P16220-1Reactome: R-HSA-400253 P16220-1Reactome: R-HSA-442720 P16220-1Reactome: R-HSA-442729 P16220-1Reactome: R-HSA-442742 P16220-1Reactome: R-HSA-5674400 P16220-1Reactome: R-HSA-881907 P16220-1Reactome: R-HSA-9022692 P16220-1Reactome: R-HSA-9022699 P16220-1Reactome: R-HSA-9022702 P16220-1Reactome: R-HSA-9022707 P16220-1Reactome: R-HSA-9031628 P16220-1Reactome: R-HSA-9609690 P16220-1Reactome: R-HSA-9616222 P16220-1Reactome: R-HSA-9634638 P16220-1Reactome: R-HSA-9660821 P16220-1Reactome: R-HSA-9664323 P16220-1Reactome: R-HSA-9707616 P16220-1Reactome: R-HSA-9824585 P16220-1Reactome: R-HSA-9856649 P16220-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 1 antibodyAnti-Creb-1 antibodyAnti-Camp-Responsive Element-Binding Protein 1 antibodyAnti-CREB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
