Anti-CRB3 antibody (STJA0008506)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CRB3
General Information
| Short Description | Rabbit polyclonal anti-Protein crumbs homolog 3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRB3 |
| Gene ID | 92359 |
| Uniprot ID | CRUM3_HUMAN |
| Immunogen | Synthesized peptide derived from human CRB3 |
| Specificity | This antibody detects endogenous levels of CRB3 at Human, Mouse |
Additional Info
| Function | Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7. |
| Protein Name | Protein Crumbs Homolog 3 |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9705677 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocalizes Primarily To The Apical Membrane With A Small Fraction In The Upper Part Of Tight Junctions Of Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Crumbs Homolog 3 antibodyAnti-CRB3 antibodyAnti-UNQ588 antibodyAnti-PRO1158 antibody |
Information sourced from Uniprot.org