| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein crumbs homolog 3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRB3 |
| Gene ID: | 92359 |
| Uniprot ID: | CRUM3_HUMAN |
| Specificity: | This antibody detects endogenous levels of CRB3 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human CRB3 |
| Function | Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7. |
| Protein Name | Protein Crumbs Homolog 3 |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9705677 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocalizes Primarily To The Apical Membrane With A Small Fraction In The Upper Part Of Tight Junctions Of Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Crumbs Homolog 3 antibodyAnti-CRB3 antibodyAnti-UNQ588 antibodyAnti-PRO1158 antibody |
Information sourced from Uniprot.org
