| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRAT |
| Gene ID: | 1384 |
| Uniprot ID: | CACP_HUMAN |
| Immunogen Region: | 380-626 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-626 of human CRAT (NP_000746.3). |
| Immunogen Sequence: | KLRFNITPEIKSDIEKAKQN LSIMIQDLDITVMVFHHFGK DFPKSEKLSPDAFIQMALQL AYYRIYGQACATYESASLRM FHLGRTDTIRSASMDSLTFV KAMDDSSVTEHQKVELLRKA VQAHRGYTDRAIRGEAFDRH LLGLKLQAIEDLVSMPDIFM DTSYAIAMHFHLSTSQVPAK TDCVMFFGPVVPDGYGVCYN PMEAHINFSLSAYNSCAETN AARLAHYLEKALLDMRALL |
| Tissue Specificity | Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney. |
| Function | Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. |
| Protein Name | Carnitine O-AcetyltransferaseCarnitine AcetylaseCarnitine AcetyltransferaseCatCrat |
| Database Links | Reactome: R-HSA-389887Reactome: R-HSA-9033241 |
| Cellular Localisation | Endoplasmic ReticulumPeroxisomeMitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideIsoform 1: MitochondrionIsoform 2: Peroxisome |
| Alternative Antibody Names | Anti-Carnitine O-Acetyltransferase antibodyAnti-Carnitine Acetylase antibodyAnti-Carnitine Acetyltransferase antibodyAnti-Cat antibodyAnti-Crat antibodyAnti-CRAT antibodyAnti-CAT1 antibody |
Information sourced from Uniprot.org