| Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. |
| Post Translational Modifications | Cleaved into an alpha and beta chain by autocatalysis.this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity. |
| Function | Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. |
| Protein Name | Isoaspartyl Peptidase/L-AsparaginaseAsparaginase-Like Protein 1Beta-Aspartyl-PeptidaseIsoaspartyl DipeptidaseL-Asparagine Amidohydrolase Cleaved Into - Isoaspartyl Peptidase/L-Asparaginase Alpha Chain - Isoaspartyl Peptidase/L-Asparaginase Beta Chain |
| Database Links | Reactome: R-HSA-8964208 |
| Cellular Localisation | CytoplasmMidpiece Of Sperm Tail |
| Alternative Antibody Names | Anti-Isoaspartyl Peptidase/L-Asparaginase antibodyAnti-Asparaginase-Like Protein 1 antibodyAnti-Beta-Aspartyl-Peptidase antibodyAnti-Isoaspartyl Dipeptidase antibodyAnti-L-Asparagine Amidohydrolase Cleaved Into - Isoaspartyl Peptidase/L-Asparaginase Alpha Chain - Isoaspartyl Peptidase/L-Asparaginase Beta Chain antibodyAnti-ASRGL1 antibodyAnti-ALP antibodyAnti-CRASH antibody |
Information sourced from Uniprot.org
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