| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:5000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPT1A |
| Gene ID: |
1374 |
| Uniprot ID: |
CPT1A_HUMAN |
| Immunogen Region: |
520-720 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 520-720 of human CPT1A (NP_001867.2). |
| Immunogen Sequence: |
WDIPGECQEVIETSLNTANL LANDVDFHSFPFVAFGKGII KKCRTSPDAFVQLALQLAHY KDMGKFCLTYEASMTRLFRE GRTETVRSCTTESCDFVRAM VDPAQTVEQRLKLFKLASEK HQHMYRLAMTGSGIDRHLFC LYVVSKYLAVESPFLKEVLS EPWRLSTSQTPQQQVELFDL ENNPEYVSSGGGFGPVADDG Y |
| Tissue Specificity | Strong expression in kidney and heart, and lower in liver and skeletal muscle. |
| Function | Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Possesses also a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity. Plays an important role in hepatic triglyceride metabolism. Plays also a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression. Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation. Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways. |
| Protein Name | Carnitine O-Palmitoyltransferase 1 - Liver IsoformCpt1-LCarnitine O-Palmitoyltransferase I - Liver IsoformCpt ICpti-LCarnitine Palmitoyltransferase 1aSuccinyltransferase Cpt1a |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1989781Reactome: R-HSA-200425Reactome: R-HSA-5362517 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Carnitine O-Palmitoyltransferase 1 - Liver Isoform antibodyAnti-Cpt1-L antibodyAnti-Carnitine O-Palmitoyltransferase I - Liver Isoform antibodyAnti-Cpt I antibodyAnti-Cpti-L antibodyAnti-Carnitine Palmitoyltransferase 1a antibodyAnti-Succinyltransferase Cpt1a antibodyAnti-CPT1A antibodyAnti-CPT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
