| Short Description : | Rabbit polyclonal CPNE3 (238-537) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CPNE3 |
| Gene ID: | 8895 |
| Uniprot ID: | CPNE3_HUMAN |
| Immunogen Region: | 238-537 |
| Immunogen Sequence: | EASRSSPVEFECINEKKRQK KKSYKNSGVISVKQCEITVE CTFLDYIMGGCQLNFTVGVD FTGSNGDPRSPDSLHYISPN GVNEYLTALWSVGLVIQDYD ADKMFPAFGFGAQIPPQWQV SHEFPMNFNPSNPYCNGIQG IVEAYRSCLPQIKLYGPTNF SPIINHVARFAAAATQQQTA SQYFVLLIITDGVITDLDET RQAIVNASRLPMSIIIVGVG GADFSAMEFLDGDGGSLRS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 238-537 of human CPNE3 (NP_003900.1). |
| Tissue Specificity | Expressed in breast and weakly in prostate and ovarian tissues. Expressed in neutrophils (at protein level). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood. Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. |
| Function | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation. |
| Protein Name | Copine-3Copine Iii |
| Database Links | Reactome: R-HSA-1483206Reactome: R-HSA-6798695 |
| Cellular Localisation | NucleusCytoplasmCell MembraneCell JunctionFocal AdhesionAssociates To The Membrane In A Calcium-Dependent MannerTranslocates To The Cell Membrane And The Nucleus In A Calcium- Or Growth Factor Heregulin-Dependent MannerColocalizes With The Tyrosine Phosphorylated Erbb2 Form At Cell Membrane And Focal Adhesions In A Calcium- Or Growth Factor Heregulin-Dependent Manner |
| Alternative Antibody Names | Anti-Copine-3 antibodyAnti-Copine Iii antibodyAnti-CPNE3 antibodyAnti-CPN3 antibodyAnti-KIAA0636 antibody |
Information sourced from Uniprot.org
