| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CPNE3 (238-537) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPNE3 |
| Gene ID: |
8895 |
| Uniprot ID: |
CPNE3_HUMAN |
| Immunogen Region: |
238-537 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 238-537 of human CPNE3 (NP_003900.1). |
| Immunogen Sequence: |
EASRSSPVEFECINEKKRQK KKSYKNSGVISVKQCEITVE CTFLDYIMGGCQLNFTVGVD FTGSNGDPRSPDSLHYISPN GVNEYLTALWSVGLVIQDYD ADKMFPAFGFGAQIPPQWQV SHEFPMNFNPSNPYCNGIQG IVEAYRSCLPQIKLYGPTNF SPIINHVARFAAAATQQQTA SQYFVLLIITDGVITDLDET RQAIVNASRLPMSIIIVGVG GADFSAMEFLDGDGGSLRS |
| Tissue Specificity | Expressed in breast and weakly in prostate and ovarian tissues. Expressed in neutrophils (at protein level). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood. Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. |
| Function | Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation. |
| Protein Name | Copine-3Copine Iii |
| Database Links | Reactome: R-HSA-1483206Reactome: R-HSA-6798695 |
| Cellular Localisation | NucleusCytoplasmCell MembraneCell JunctionFocal AdhesionAssociates To The Membrane In A Calcium-Dependent MannerTranslocates To The Cell Membrane And The Nucleus In A Calcium- Or Growth Factor Heregulin-Dependent MannerColocalizes With The Tyrosine Phosphorylated Erbb2 Form At Cell Membrane And Focal Adhesions In A Calcium- Or Growth Factor Heregulin-Dependent Manner |
| Alternative Antibody Names | Anti-Copine-3 antibodyAnti-Copine Iii antibodyAnti-CPNE3 antibodyAnti-CPN3 antibodyAnti-KIAA0636 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
