Western blot analysis of various lysates using CPNE3 Rabbit polyclonal antibody (STJ116891) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-CPNE3 antibody (238-537) (STJ116891)

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STJ116891
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CPNE3
Gene ID: 8895
Uniprot ID: CPNE3_HUMAN
Immunogen Region: 238-537
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 238-537 of human CPNE3 (NP_003900.1).
Immunogen Sequence: EASRSSPVEFECINEKKRQK KKSYKNSGVISVKQCEITVE CTFLDYIMGGCQLNFTVGVD FTGSNGDPRSPDSLHYISPN GVNEYLTALWSVGLVIQDYD ADKMFPAFGFGAQIPPQWQV SHEFPMNFNPSNPYCNGIQG IVEAYRSCLPQIKLYGPTNF SPIINHVARFAAAATQQQTA SQYFVLLIITDGVITDLDET RQAIVNASRLPMSIIIVGVG GADFSAMEFLDGDGGSLRS
Tissue Specificity Expressed in breast and weakly in prostate and ovarian tissues. Expressed in neutrophils (at protein level). Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood. Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma.
Post Translational Modifications Phosphorylated on serine and threonine residues.
Function Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.
Protein Name Copine-3
Copine Iii
Database Links Reactome: R-HSA-1483206
Reactome: R-HSA-6798695
Cellular Localisation Nucleus
Cytoplasm
Cell Membrane
Cell Junction
Focal Adhesion
Associates To The Membrane In A Calcium-Dependent Manner
Translocates To The Cell Membrane And The Nucleus In A Calcium- Or Growth Factor Heregulin-Dependent Manner
Colocalizes With The Tyrosine Phosphorylated Erbb2 Form At Cell Membrane And Focal Adhesions In A Calcium- Or Growth Factor Heregulin-Dependent Manner
Alternative Antibody Names Anti-Copine-3 antibody
Anti-Copine Iii antibody
Anti-CPNE3 antibody
Anti-CPN3 antibody
Anti-KIAA0636 antibody

Information sourced from Uniprot.org

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