| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | CPB2 |
| Gene ID: | 1361 |
| Uniprot ID: | CBPB2_HUMAN |
| Immunogen Region: | 115-365 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-365 of human CPB2 (NP_001863.2). |
| Immunogen Sequence: | ASASYYEQYHSLNEIYSWIE FITERHPDMLTKIHIGSSFE KYPLYVLKVSGKEQAAKNAI WIDCGIHAREWISPAFCLWF IGHITQFYGIIGQYTNLLRL VDFYVMPVVNVDGYDYSWKK NRMWRKNRSFYANNHCIGTD LNRNFASKHWCEEGASSSSC SETYCGLYPESEPEVKAVAS FLRRNINQIKAYISMHSYSQ HIVFPYSYTRSKSKDHEELS LVASEAVRAIEKTSKNTRY |
| Tissue Specificity | Plasma.synthesized in the liver. |
| Post Translational Modifications | N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4. |
| Function | Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. |
| Protein Name | Carboxypeptidase B2Carboxypeptidase UCpuPlasma Carboxypeptidase BPcpbThrombin-Activable Fibrinolysis InhibitorTafi |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Carboxypeptidase B2 antibodyAnti-Carboxypeptidase U antibodyAnti-Cpu antibodyAnti-Plasma Carboxypeptidase B antibodyAnti-Pcpb antibodyAnti-Thrombin-Activable Fibrinolysis Inhibitor antibodyAnti-Tafi antibodyAnti-CPB2 antibody |
Information sourced from Uniprot.org
