| Function | Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism. Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association. Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV. Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV. The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis. |
| Protein Name | Cytochrome C Oxidase Subunit 7a2-Like - MitochondrialCytochrome C Oxidase Subunit 7a-Related ProteinCox7a-Related ProteinCytochrome C Oxidase Subunit Viia-Related ProteinEb1Supercomplex Assembly Factor 1 |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9707564Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome C Oxidase Subunit 7a2-Like - Mitochondrial antibodyAnti-Cytochrome C Oxidase Subunit 7a-Related Protein antibodyAnti-Cox7a-Related Protein antibodyAnti-Cytochrome C Oxidase Subunit Viia-Related Protein antibodyAnti-Eb1 antibodyAnti-Supercomplex Assembly Factor 1 antibodyAnti-COX7A2L antibodyAnti-COX7AR antibodyAnti-COX7RP antibodyAnti-SCAF1 antibodyAnti-SCAFI antibody |
Information sourced from Uniprot.org
