• Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-COX6B2 antibody (40-120 aa) (STJ196512)

SKU:
STJ196512

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cytochrome c oxidase subunit 6B2 (40-120 aa) is suitable for use in Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
ELISA-Pep 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COX6B2
Gene ID: 125965
Uniprot ID: CX6B2_HUMAN
Immunogen Region: 40-120 aa
Specificity: This antibody detects endogenous levels of human COX6B2
Immunogen: Synthesized peptide derived from the human COX6B2 at the amino acid range 40-120
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Protein Name Cytochrome C Oxidase Subunit 6b2
Cancer/Testis Antigen 59
Ct59
Cytochrome C Oxidase Subunit Vib Isoform 2
Cox Vib-2
Cytochrome C Oxidase Subunit Vib - Testis-Specific Isoform
Cellular Localisation Mitochondrion Inner Membrane
Peripheral Membrane Protein
Intermembrane Side
Alternative Antibody Names Anti-Cytochrome C Oxidase Subunit 6b2 antibody
Anti-Cancer/Testis Antigen 59 antibody
Anti-Ct59 antibody
Anti-Cytochrome C Oxidase Subunit Vib Isoform 2 antibody
Anti-Cox Vib-2 antibody
Anti-Cytochrome C Oxidase Subunit Vib - Testis-Specific Isoform antibody
Anti-COX6B2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance