| Host: |
Mouse |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Cytochrome c oxidase subunit 4 isoform 1, mitochondrial is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
6C8 |
| Conjugation: |
AbFluor™ 488 |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS pH7.4, containing 0.02% Sodium Azide and 50% Glycerol. |
| Purification: |
The antibody was purified using affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
Optimal working dilutions should be determined experimentally by the investigator Suggested starting dilutions are as follows: IHC 1:50-300 IF 1:200 |
| Storage Instruction: |
Stable for one year at-15°C to-25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezi |
| Gene Symbol: |
COX4I1 |
| Gene ID: |
1327 |
| Uniprot ID: |
COX41_HUMAN |
| Specificity: |
COX IV Monoclonal Antibody (6C8) AbFluor™ 488 Conjugated specially designed for your Immunofluorescence analysis. |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. |
| Protein Name | Cytochrome C Oxidase Subunit 4 Isoform 1 - MitochondrialCytochrome C Oxidase Polypeptide IvCytochrome C Oxidase Subunit Iv Isoform 1Cox Iv-1 |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9707564 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome C Oxidase Subunit 4 Isoform 1 - Mitochondrial antibodyAnti-Cytochrome C Oxidase Polypeptide Iv antibodyAnti-Cytochrome C Oxidase Subunit Iv Isoform 1 antibodyAnti-Cox Iv-1 antibodyAnti-COX4I1 antibodyAnti-COX4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
