| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COTL1 |
| Gene ID: | 23406 |
| Uniprot ID: | COTL1_HUMAN |
| Immunogen Region: | 1-142 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human COTL1 (NP_066972.1). |
| Immunogen Sequence: | MATKIDKEACRAAYNLVRDD GSAVIWVTFKYDGSTIVPGE QGAEYQHFIQQCTDDVRLFA FVRFTTGDAMSKRSKFALIT WIGENVSGLQRAKTGTDKTL VKEVVQNFAKEFVISDRKEL EEDFIKSELKKAGGANYDAQ TE |
| Tissue Specificity | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. |
| Function | Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. |
| Protein Name | Coactosin-Like Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoskeletonNucleus |
| Alternative Antibody Names | Anti-Coactosin-Like Protein antibodyAnti-COTL1 antibodyAnti-CLP antibody |
Information sourced from Uniprot.org