| Host: | Rabbit |
| Applications: | WB/ICC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Coronin-1B (C-Term) is suitable for use in Western Blot and Immunocytochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:1000ICC 1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CORO1B |
| Gene ID: | 57175 |
| Uniprot ID: | COR1B_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | The antibody detects a 60 kDa* band corresponding to Coronin-1B on SDS-PAGE immunoblots of human A431 and HeLa, mouse brain, and rabbit spleen fibroblasts. |
| Immunogen: | Coronin-1B (C-terminus) synthetic peptide (coupled to carrier protein) corresponds to amino acids at the C-terminus of human coronin-1B. This sequence has high homology to the conserved site in rat and mouse coronin-1B, and less than 50% homology to |
| Post Translational Modifications | Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location. |
| Function | Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction. |
| Protein Name | Coronin-1bCoronin-2 |
| Cellular Localisation | CytoplasmCytoskeletonStress FiberLocalized To The Leading Edge In FibroblastsAs Well As Weakly Along Actin Stress Fibers |
| Alternative Antibody Names | Anti-Coronin-1b antibodyAnti-Coronin-2 antibodyAnti-CORO1B antibody |
Information sourced from Uniprot.org
