Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-CORO1A (362-461) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CORO1A |
Gene ID: | 11151 |
Uniprot ID: | COR1A_HUMAN |
Immunogen Region: | 362-461 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 362-461 of human CORO1A (NP_001180262.1). |
Immunogen Sequence: | DLYPPTAGPDPALTAEEWLG GRDAGPLLISLKDGYVPPKS RELRVNRGLDTGRRRAAPEA SGTPSSDAVSRLEEEMRKLQ ATVQELQKRLDRLEETVQAK |
Tissue Specificity | Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut. |
Post Translational Modifications | phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin. Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation. |
Function | May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. |
Protein Name | Coronin-1a Coronin-Like Protein A Clipin-A Coronin-Like Protein P57 Tryptophan Aspartate-Containing Coat Protein Taco |
Database Links | Reactome: R-HSA-9636383 |
Cellular Localisation | Cytoplasm Cytoskeleton Cell Cortex Cytoplasmic Vesicle Phagosome Membrane In Non-Infected Macrophages Associated With The Cortical Microtubule Network In Mycobacteria-Infected Macrophages Becomes Progressively Relocalized And Retained Around The Mycobacterial Phagosomes Retention On The Phagosomal Membrane Is Strictly Dependent On Mycobacterial Viability And Not Due To Impaired Acidification |
Alternative Antibody Names | Anti-Coronin-1a antibody Anti-Coronin-Like Protein A antibody Anti-Clipin-A antibody Anti-Coronin-Like Protein P57 antibody Anti-Tryptophan Aspartate-Containing Coat Protein antibody Anti-Taco antibody Anti-CORO1A antibody Anti-CORO1 antibody |
Information sourced from Uniprot.org