| Tissue Specificity | Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut. |
| Post Translational Modifications | phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin. Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation. |
| Function | May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. |
| Protein Name | Coronin-1aCoronin-Like Protein AClipin-ACoronin-Like Protein P57Tryptophan Aspartate-Containing Coat ProteinTaco |
| Database Links | Reactome: R-HSA-9636383 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesiclePhagosome MembraneIn Non-Infected MacrophagesAssociated With The Cortical Microtubule NetworkIn Mycobacteria-Infected MacrophagesBecomes Progressively Relocalized And Retained Around The Mycobacterial PhagosomesRetention On The Phagosomal Membrane Is Strictly Dependent On Mycobacterial Viability And Not Due To Impaired Acidification |
| Alternative Antibody Names | Anti-Coronin-1a antibodyAnti-Coronin-Like Protein A antibodyAnti-Clipin-A antibodyAnti-Coronin-Like Protein P57 antibodyAnti-Tryptophan Aspartate-Containing Coat Protein antibodyAnti-Taco antibodyAnti-CORO1A antibodyAnti-CORO1 antibody |
Information sourced from Uniprot.org
