| Short Description : | Rabbit polyclonal COQ9 (1-318) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COQ9 |
| Gene ID: | 57017 |
| Uniprot ID: | COQ9_HUMAN |
| Immunogen Region: | 1-318 |
| Immunogen Sequence: | MAAAAVSGALGRAGWRLLQL RCLPVARCRQALVPRAFHAS AVGLRSSDEQKQQPPNSFSQ QHSETQGAEKPDPESSHSPP RYTDQGGEEEEDYESEEQLQ HRILTAALEFVPAHGWTAEA IAEGAQSLGLSSAAASMFGK DGSELILHFVTQCNTRLTRV LEEEQKLVQLGQAEKRKTDQ FLRDAVETRLRMLIPYIEHW PRALSILMLPHNIPSSLSLL TSMVDDMWHYAGDQSTDFN |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human COQ9 (NP_064708.1). |
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. |
| Protein Name | Ubiquinone Biosynthesis Protein Coq9 - Mitochondrial |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | MitochondrionAssociates With Cardiolipin-Rich Membranes Which Leads To The Lipid Bilayer Deformation And Then Accessing To Membrane-Bound Lipids |
| Alternative Antibody Names | Anti-Ubiquinone Biosynthesis Protein Coq9 - Mitochondrial antibodyAnti-COQ9 antibodyAnti-C16orf49 antibodyAnti-HSPC326 antibodyAnti-PSEC0129 antibody |
Information sourced from Uniprot.org
