| Short Description : | Rabbit polyclonal anti-Atypical kinase COQ8B, mitochondrial (31-80 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COQ8B |
| Gene ID: | 79934 |
| Uniprot ID: | COQ8B_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ADCK4 at the amino acid range 31-80 |
| Immunogen Region: | 31-80 aa |
| Specificity: | ADCK4 Polyclonal Antibody detects endogenous levels of ADCK4 protein. |
| Function | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. However, the small molecule kinase activity was not confirmed by another publication. Required for podocyte migration. |
| Protein Name | Atypical Kinase Coq8b - MitochondrialAarf Domain-Containing Protein Kinase 4Coenzyme Q Protein 8b |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmCytosolCell Membrane |
| Alternative Antibody Names | Anti-Atypical Kinase Coq8b - Mitochondrial antibodyAnti-Aarf Domain-Containing Protein Kinase 4 antibodyAnti-Coenzyme Q Protein 8b antibodyAnti-COQ8B antibodyAnti-ADCK4 antibody |
Information sourced from Uniprot.org
