• Western blot analysis of the lysates from 293 cells using COPS2 antibody.
  • Immunofluorescence analysis of A549 cells, using COPS2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from COS7 and COLO205 cells, using COPS2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-COPS2 antibody (181-230 aa) (STJ96104)

SKU:
STJ96104

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-COP9 signalosome complex subunit 2 (181-230 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COPS2
Gene ID: 9318
Uniprot ID: CSN2_HUMAN
Immunogen Region: 181-230 aa
Specificity: TRIP15 Polyclonal Antibody detects endogenous levels of TRIP15 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human COPS2 at the amino acid range 181-230
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Protein Name Cop9 Signalosome Complex Subunit 2
Sgn2
Signalosome Subunit 2
Alien Homolog
Jab1-Containing Signalosome Subunit 2
Thyroid Receptor-Interacting Protein 15
Tr-Interacting Protein 15
Trip-15
Database Links Reactome: R-HSA-5696394
Reactome: R-HSA-6781823
Reactome: R-HSA-8856825
Reactome: R-HSA-8951664
Reactome: R-HSA-9013422
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Cop9 Signalosome Complex Subunit 2 antibody
Anti-Sgn2 antibody
Anti-Signalosome Subunit 2 antibody
Anti-Alien Homolog antibody
Anti-Jab1-Containing Signalosome Subunit 2 antibody
Anti-Thyroid Receptor-Interacting Protein 15 antibody
Anti-Tr-Interacting Protein 15 antibody
Anti-Trip-15 antibody
Anti-COPS2 antibody
Anti-CSN2 antibody
Anti-TRIP15 antibody

Information sourced from Uniprot.org

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