| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins.the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. |
| Protein Name | Coatomer Subunit Gamma-2Gamma-2-Coat ProteinGamma-2-Cop |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | CytoplasmCytosolGolgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleCopi-Coated Vesicle MembraneThe Coatomer Is Cytoplasmic Or Polymerized On The Cytoplasmic Side Of The GolgiAs Well As On The Vesicles/Buds Originating From ItTends To Be More Abundant In The Trans-Golgi Network Compared To The Cis-Golgi |
| Alternative Antibody Names | Anti-Coatomer Subunit Gamma-2 antibodyAnti-Gamma-2-Coat Protein antibodyAnti-Gamma-2-Cop antibodyAnti-COPG2 antibody |
Information sourced from Uniprot.org
