Anti-COPG1 antibody (555-874) (STJ112569)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COPG1 (555-874) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COPG1 |
| Gene ID | 22820 |
| Uniprot ID | COPG1_HUMAN |
| Immunogen Region | 555-874 |
| Immunogen Sequence | IPGLERALQQYTLEPSEKPF DLKSVPLATAPMAEQRTEST PITAVKQPEKVAATRQEIFQ EQLAAVPEFRGLGPLFKSSP EPVALTESETEYVIRCTKHT FTNHMVFQFDCTNTLNDQTL ENVTVQMEPTEAYEVLCYVP ARSLPYNQPGTCYTLVALPK EDPTAVACTFSCMMKFTVKD CDPTTGETDDEGYEDEYVLE DLEVTVADHIQKVMKLNFEA AWDEVGDEFEKEETFTLST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 555-874 of human COPG1 (NP_057212.1). |
Additional Info
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins.the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis. |
| Protein Name | Coatomer Subunit Gamma-1Gamma-1-Coat ProteinGamma-1-Cop |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleCopi-Coated Vesicle MembraneThe Coatomer Is Cytoplasmic Or Polymerized On The Cytoplasmic Side Of The GolgiAs Well As On The Vesicles/Buds Originating From ItPredominantly Located In The Cis-Golgi Apparatus |
| Alternative Antibody Names | Anti-Coatomer Subunit Gamma-1 antibodyAnti-Gamma-1-Coat Protein antibodyAnti-Gamma-1-Cop antibodyAnti-COPG1 antibodyAnti-COPG antibody |
Information sourced from Uniprot.org