| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COPE (1-308) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COPE |
| Gene ID: |
11316 |
| Uniprot ID: |
COPE_HUMAN |
| Immunogen Region: |
1-308 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-308 of human COPE (NP_009194.2). |
| Immunogen Sequence: |
MAPPAPGPASGGSGEVDELF DVKNAFYIGSYQQCINEAQR VKLSSPERDVERDVFLYRAY LAQRKFGVVLDEIKPSSAPE LQAVRMFADYLAHESRRDSI VAELDREMSRSVDVTNTTFL LMAASIYLHDQNPDAALRAL HQGDSLECTAMTVQILLKLD RLDLARKELKRMQDLDEDAT LTQLATAWVSLATGGEKLQD AYYIFQEMADKCSPTLLLLN GQAACHMAQGRWEAAEGLL |
| Post Translational Modifications | Phosphorylated by PKA. Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation. |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins.the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. |
| Protein Name | Coatomer Subunit EpsilonEpsilon-Coat ProteinEpsilon-Cop |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleCopi-Coated Vesicle MembraneThe Coatomer Is Cytoplasmic Or Polymerized On The Cytoplasmic Side Of The GolgiAs Well As On The Vesicles/Buds Originating From It |
| Alternative Antibody Names | Anti-Coatomer Subunit Epsilon antibodyAnti-Epsilon-Coat Protein antibodyAnti-Epsilon-Cop antibodyAnti-COPE antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
