| Short Description : | Goat polyclonal antibody anti-contactin 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/WB/IHC |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 140kDa band observed in Human, Mouse, Rat and Pig Brain lysates (calculated MW of 113kDa according to NP_001834.2). The observed molecular weight corresponds to the glycosylated |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CNTN1 |
| Gene ID: | 1272 |
| Uniprot ID: | CNTN1_HUMAN |
| Accession Number: | NP_001834.2; NP_778203.1; NP_001242992.1 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | ENIRGKDKHQAR |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1. |
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. |
| Protein Name | Contactin-1Glycoprotein Gp135Neural Cell Surface Protein F3 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2979096Reactome: R-HSA-373760Reactome: R-HSA-447043 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Contactin-1 antibodyAnti-Glycoprotein Gp135 antibodyAnti-Neural Cell Surface Protein F3 antibodyAnti-CNTN1 antibody |
Information sourced from Uniprot.org
