Anti-contactin 1 antibody (Internal) (STJ73052)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-contactin 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 140kDa band observed in Human, Mouse, Rat and Pig Brain lysates (calculated MW of 113kDa according to NP_001834.2). The observed molecular weight corresponds to the glycosylated |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CNTN1 |
| Gene ID | 1272 |
| Uniprot ID | CNTN1_HUMAN |
| Accession Number | NP_001834.2; NP_778203.1; NP_001242992.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | ENIRGKDKHQAR |
| Specificity | This antibody is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1. |
Additional Info
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. |
| Protein Name | Contactin-1Glycoprotein Gp135Neural Cell Surface Protein F3 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2979096Reactome: R-HSA-373760Reactome: R-HSA-447043 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Contactin-1 antibodyAnti-Glycoprotein Gp135 antibodyAnti-Neural Cell Surface Protein F3 antibodyAnti-CNTN1 antibody |
Information sourced from Uniprot.org