| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Pig |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-contactin 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.3-1µg/mlIHC-5µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CNTN1 |
| Gene ID: |
1272 |
| Uniprot ID: |
CNTN1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001834.2; NP_778203.1; NP_001242992.1 |
| Specificity: |
This antibody is expected to recognize all reported isoforms (NP_001834.2; NP_778203.1; NP_001242992.1). Reported variants represent identical protein: NP_001242993.1, NP_001242992.1. |
| Immunogen Sequence: |
ENIRGKDKHQAR |
| Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. |
| Protein Name | Contactin-1Glycoprotein Gp135Neural Cell Surface Protein F3 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2979096Reactome: R-HSA-373760Reactome: R-HSA-447043 |
| Cellular Localisation | Isoform 1: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Contactin-1 antibodyAnti-Glycoprotein Gp135 antibodyAnti-Neural Cell Surface Protein F3 antibodyAnti-CNTN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
