| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Rat/Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Complexin-2 (40-80 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:3000 to 1:4000 is recommended for WB and 1:1000 to 1:2000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
CPLX2 |
| Gene ID: |
10814 |
| Uniprot ID: |
CPLX2_HUMAN |
| Immunogen Region: |
40-80 aa |
| Specificity: |
Specific for Complexin-2. |
| Immunogen: |
A synthetic peptide from aa region 40-80 of human Complexin-2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Function | Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis. |
| Protein Name | Complexin-2Complexin IiCpx IiSynaphin-1 |
| Cellular Localisation | CytoplasmCytosolPresynapseNucleusPerikaryonTranslocated From The Perikaryon To The Presynaptic Terminals During Maturation Of Neuronal CellsIn Mast CellsCytosol And NucleusBecomes Enriched Near Plasma Membrane Following Stimulation |
| Alternative Antibody Names | Anti-Complexin-2 antibodyAnti-Complexin Ii antibodyAnti-Cpx Ii antibodyAnti-Synaphin-1 antibodyAnti-CPLX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
