| Short Description : | Rabbit polyclonal anti-Comm Domain-Containing Protein 6 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1.4 mg/mL |
| Purification: | Antigen affinity purification |
| Dilution Range: | IHC 1:30-1:150 |
| Formulation: | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction: | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | COMMD6 |
| Gene ID: | 170622 |
| Uniprot ID: | COMD6_HUMAN |
| Immunogen: | Full length fusion protein |
| Tissue Specificity | Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. |
| Protein Name | Comm Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 6 antibodyAnti-COMMD6 antibodyAnti-MSTP076 antibody |
Information sourced from Uniprot.org
