Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-COMM domain-containing protein 5 (47-97) is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:1000-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | COMMD5 |
Gene ID: | 28991 |
Uniprot ID: | COMD5_HUMAN |
Immunogen Region: | 47-97 |
Specificity: | This antibody detects endogenous levels of human COMD5 |
Immunogen: | Synthesized peptide derived from human COMD5 AA range: 47-97 |
Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. |
Protein Name | Comm Domain-Containing Protein 5Hypertension-Related Calcium-Regulated Gene ProteinHcarg |
Database Links | Reactome: R-HSA-8951664 |
Cellular Localisation | CytoplasmNucleus |
Alternative Antibody Names | Anti-Comm Domain-Containing Protein 5 antibodyAnti-Hypertension-Related Calcium-Regulated Gene Protein antibodyAnti-Hcarg antibodyAnti-COMMD5 antibodyAnti-HT002 antibody |
Information sourced from Uniprot.org