| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-COMM domain-containing protein 5 (47-97) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COMMD5 |
| Gene ID: | 28991 |
| Uniprot ID: | COMD5_HUMAN |
| Immunogen Region: | 47-97 |
| Specificity: | This antibody detects endogenous levels of human COMD5 |
| Immunogen: | Synthesized peptide derived from human COMD5 AA range: 47-97 |
| Function | Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos.the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. |
| Protein Name | Comm Domain-Containing Protein 5Hypertension-Related Calcium-Regulated Gene ProteinHcarg |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 5 antibodyAnti-Hypertension-Related Calcium-Regulated Gene Protein antibodyAnti-Hcarg antibodyAnti-COMMD5 antibodyAnti-HT002 antibody |
Information sourced from Uniprot.org
