| Host: | Rabbit |
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | COL4A5 |
| Gene ID: | 1287 |
| Uniprot ID: | CO4A5_HUMAN |
| Immunogen Region: | 1462-1691 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1). |
| Immunogen Sequence: | SSVAHGFLITRHSQTTDAPQ CPQGTLQVYEGFSLLYVQGN KRAHGQDLGTAGSCLRRFST MPFMFCNINNVCNFASRNDY SYWLSTPEPMPMSMQPLKGQ SIQPFISRCAVCEAPAVVIA VHSQTIQIPHCPQGWDSLWI GYSFMMHTSAGAEGSGQALA SPGSCLEEFRSAPFIECHGR GTCNYYANSYSFWLATVDVS DMFSKPQSETLKAGDLRTRI SRCQVCMKRT |
| Tissue Specificity | Isoform 2 is found in kidney. |
| Post Translational Modifications | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues. |
| Function | Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. |
| Protein Name | Collagen Alpha-5(Iv Chain |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474244Reactome: R-HSA-1650814Reactome: R-HSA-186797Reactome: R-HSA-2022090Reactome: R-HSA-216083Reactome: R-HSA-2214320Reactome: R-HSA-2243919Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-419037Reactome: R-HSA-8948216Reactome: R-HSA-9010553 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement Membrane |
| Alternative Antibody Names | Anti-Collagen Alpha-5(Iv Chain antibodyAnti-COL4A5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
