| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CERT1 |
| Gene ID: | 10087 |
| Uniprot ID: | CERT_HUMAN |
| Immunogen Region: | 369-598 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 369-598 of human COL4A3BP (NP_112729.1). |
| Immunogen Sequence: | QKVEEMVQNHMTYSLQDVGG DANWQLVVEEGEMKVYRREV EENGIVLDPLKATHAVKGVT GHEVCNYFWNVDVRNDWETT IENFHVVETLADNAIIIYQT HKRVWPASQRDVLYLSVIRK IPALTENDPETWIVCNFSVD HDSAPLNNRCVRAKINVAMI CQTLVSPPEGNQEISRDNIL CKITYVANVNPGGWAPASVL RAVAKREYPKFLKRFTSYVQ EKTAGKPILF |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. |
| Function | Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. |
| Protein Name | Ceramide Transfer Protein Hcert Collagen Type Iv Alpha-3-Binding Protein Goodpasture Antigen-Binding Protein Gpbp Start Domain-Containing Protein 11 Stard11 Star-Related Lipid Transfer Protein 11 |
| Database Links | Reactome: R-HSA-1660661 Q9Y5P4-2 |
| Cellular Localisation | Cytoplasm Golgi Apparatus Endoplasmic Reticulum Preferentially Localized To The Golgi Apparatus |
| Alternative Antibody Names | Anti-Ceramide Transfer Protein antibody Anti-Hcert antibody Anti-Collagen Type Iv Alpha-3-Binding Protein antibody Anti-Goodpasture Antigen-Binding Protein antibody Anti-Gpbp antibody Anti-Start Domain-Containing Protein 11 antibody Anti-Stard11 antibody Anti-Star-Related Lipid Transfer Protein 11 antibody Anti-CERT1 antibody Anti-CERT antibody Anti-COL4A3BP antibody Anti-STARD11 antibody |
Information sourced from Uniprot.org