| Post Translational Modifications | Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on 11% of proline residues and 49% of lysine residues. |
| Function | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| Protein Name | Collagen Alpha-1(Xxv ChainAlzheimer Disease Amyloid-Associated ProteinAmyClac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque ComponentClac |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1650814Reactome: R-HSA-8948216 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinAfter Proteolytic CleavageClac Is Secreted |
| Alternative Antibody Names | Anti-Collagen Alpha-1(Xxv Chain antibodyAnti-Alzheimer Disease Amyloid-Associated Protein antibodyAnti-Amy antibodyAnti-Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component antibodyAnti-Clac antibodyAnti-COL25A1 antibody |
Information sourced from Uniprot.org
