Anti-CNTN6 antibody (20-110) (STJ116487)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CNTN6 (20-110) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNTN6 |
| Gene ID | 27255 |
| Uniprot ID | CNTN6_HUMAN |
| Immunogen Region | 20-110 |
| Immunogen Sequence | DGLLSRPIFTQEPHDVIFPL DLSKSEVILNCAANGYPSPH YRWKQNGTDIDFTMSYHYRL DGGSLAINSPHTDQDIGMYQ CLATNLLGTIL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human CNTN6 (NP_055276.1). |
Additional Info
| Tissue Specificity | Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. |
| Function | Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. |
| Protein Name | Contactin-6Neural Recognition Molecule Nb-3Hnb-3 |
| Database Links | Reactome: R-HSA-447041 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Contactin-6 antibodyAnti-Neural Recognition Molecule Nb-3 antibodyAnti-Hnb-3 antibodyAnti-CNTN6 antibody |
Information sourced from Uniprot.org