| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-CNTFR (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 38-40kDa band observed in mouse brain lysates (calculated MW of 40.8kDa according to mouse NP_057882.1). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CNTFR |
| Gene ID: | 1271 |
| Uniprot ID: | CNTFR_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_671693.1; NP_001833.1 |
| Specificity: | This antibody is expected to recognise both reported isoforms (NP_671693.1; NP_001833.1). |
| Immunogen Sequence: | CRSNTYPKGFY |
| Function | Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1. |
| Protein Name | Ciliary Neurotrophic Factor Receptor Subunit AlphaCntf Receptor Subunit AlphaCntfr-Alpha |
| Database Links | Reactome: R-HSA-6788467 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Ciliary Neurotrophic Factor Receptor Subunit Alpha antibodyAnti-Cntf Receptor Subunit Alpha antibodyAnti-Cntfr-Alpha antibodyAnti-CNTFR antibody |
Information sourced from Uniprot.org