Anti-CNGA1 antibody (401-450 aa) (STJ92360)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CNGA1 at the amino acid range 401-450
General Information
| Short Description | Rabbit polyclonal anti-cGMP-gated cation channel alpha-1 (401-450 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNGA1 |
| Gene ID | 1259 |
| Uniprot ID | CNGA1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CNGA1 at the amino acid range 401-450 |
| Immunogen Region | 401-450 aa |
| Specificity | CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein. |
Additional Info
| Function | Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-1Cng Channel Alpha-1Cng-1Cng1Cyclic Nucleotide-Gated Channel - PhotoreceptorRod Photoreceptor Cgmp-Gated Cation Channel Subunit AlphaCgmp-Gated Cation Channel Alpha-1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-1 antibodyAnti-Cng Channel Alpha-1 antibodyAnti-Cng-1 antibodyAnti-Cng1 antibodyAnti-Cyclic Nucleotide-Gated Channel - Photoreceptor antibodyAnti-Rod Photoreceptor Cgmp-Gated Cation Channel Subunit Alpha antibodyAnti-Cgmp-Gated Cation Channel Alpha-1 antibodyAnti-CNGA1 antibodyAnti-CNCG antibodyAnti-CNCG1 antibody |
Information sourced from Uniprot.org