Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CNDP2 |
Gene ID: | 55748 |
Uniprot ID: | CNDP2_HUMAN |
Immunogen Region: | 1-210 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human CNDP2 (NP_060705.2). |
Immunogen Sequence: | MAALTTLFKYIDENQDRYIK KLAKWVAIQSVSAWPEKRGE IRRMMEVAAADVKQLGGSVE LVDIGKQKLPDGSEIPLPPI LLGRLGSDPQKKTVCIYGHL DVQPAALEDGWDSEPFTLVE RDGKLYGRGSTDDKGPVAGW INALEAYQKTGQEIPVNVRF CLEGMEESGSEGLDELIFAR KDTFFKDVDYVCISDNYWLG KKKPCITYGL |
Tissue Specificity | Isoform 1: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes. Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level). Isoform 2: Broadly expressed in fetal tissues. Expressed in adult liver and placenta. |
Function | Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis. |
Protein Name | Cytosolic Non-Specific Dipeptidase Cndp Dipeptidase 2 Glutamate Carboxypeptidase-Like Protein 1 Peptidase A Threonyl Dipeptidase |
Database Links | Reactome: R-HSA-174403 Reactome: R-HSA-9753281 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Cytosolic Non-Specific Dipeptidase antibody Anti-Cndp Dipeptidase 2 antibody Anti-Glutamate Carboxypeptidase-Like Protein 1 antibody Anti-Peptidase A antibody Anti-Threonyl Dipeptidase antibody Anti-CNDP2 antibody Anti-CN2 antibody Anti-CPGL antibody Anti-HEL-S-13 antibody Anti-PEPA antibody |
Information sourced from Uniprot.org