| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 (84-183) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4775RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:10000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CMTM6 |
| Gene ID: |
54918 |
| Uniprot ID: |
CKLF6_HUMAN |
| Immunogen Region: |
84-183 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 84-183 of human CMTM6 (NP_060271.1). |
| Immunogen Sequence: |
LILIVYCTPFYERVDTTKVK SSDFYITLGTGCVFLLASII FVSTHDRTSAEIAAIVFGFI ASFMFLLDFITMLYEKRQES QLRKPENTTRAEALTEPLNA |
| Tissue Specificity | Expressed in the leukocytes, placenta and testis. |
| Function | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. |
| Protein Name | Cklf-Like Marvel Transmembrane Domain-Containing Protein 6Chemokine-Like Factor Superfamily Member 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCo-Localizes With Pd-L1/Cd274 In The Plasma Membrane And In Recycling Endosomes |
| Alternative Antibody Names | Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 6 antibodyAnti-Chemokine-Like Factor Superfamily Member 6 antibodyAnti-CMTM6 antibodyAnti-CKLFSF6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
