Anti-CMPK2 antibody (57-107 aa) (STJ195240)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CMPK2 at the amino acid range 57-107
General Information
| Short Description | Rabbit polyclonal anti-UMP-CMP kinase 2, mitochondrial (57-107 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CMPK2 |
| Gene ID | 129607 |
| Uniprot ID | CMPK2_HUMAN |
| Immunogen | Synthesized peptide derived from the human CMPK2 at the amino acid range 57-107 |
| Immunogen Region | 57-107 aa |
| Specificity | This antibody detects endogenous levels of CMPK2 at Human/Mouse |
Additional Info
| Function | Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities. Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides. CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators. In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation. |
| Protein Name | Ump-Cmp Kinase 2 - MitochondrialNucleoside-Diphosphate Kinase |
| Database Links | |
| Cellular Localisation | MitochondrionMitochondrial Localization Is Required For Its Antiviral Function |
| Alternative Antibody Names | Anti-Ump-Cmp Kinase 2 - Mitochondrial antibodyAnti-Nucleoside-Diphosphate Kinase antibodyAnti-CMPK2 antibody |
Information sourced from Uniprot.org