Anti-CMKLR1 antibody [SAA1892] (STJA0020320)

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STJA0020320
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Chemerin-Like Receptor 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1892
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: CMKLR1
Gene ID: 1240
Uniprot ID: CML1_HUMAN
Function Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Protein Name Chemerin-Like Receptor 1
Chemokine-Like Receptor 1
G-Protein Coupled Receptor Chemr23
G-Protein Coupled Receptor Dez
Database Links Reactome: R-HSA-373076
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Internalizes Efficiently In Response To Rarres2
Alternative Antibody Names Anti-Chemerin-Like Receptor 1 antibody
Anti-Chemokine-Like Receptor 1 antibody
Anti-G-Protein Coupled Receptor Chemr23 antibody
Anti-G-Protein Coupled Receptor Dez antibody
Anti-CMKLR1 antibody
Anti-CHEMR23 antibody
Anti-DEZ antibody

Information sourced from Uniprot.org