| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S1MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000IHC-P:1:100-1:800ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CMA1 |
| Gene ID: | 1215 |
| Uniprot ID: | CMA1_HUMAN |
| Immunogen Region: | 148-247 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 148-247 of human Mast Cell Chymase (CMA1) (CMA1) (P23946). |
| Immunogen Sequence: | GWGRTGVLKPGSDTLQEVKL RLMDPQACSHFRDFDHNLQL CVGNPRKTKSAFKGDSGGPL LCAGVAQGIVSYGRSDAKPP AVFTRISHYRPWINQILQAN |
| Tissue Specificity | Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. |
| Function | Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. |
| Protein Name | ChymaseAlpha-ChymaseMast Cell Protease I |
| Database Links | Reactome: R-HSA-1433557Reactome: R-HSA-1592389Reactome: R-HSA-2022377 |
| Cellular Localisation | SecretedCytoplasmic GranuleMast Cell Granules |
| Alternative Antibody Names | Anti-Chymase antibodyAnti-Alpha-Chymase antibodyAnti-Mast Cell Protease I antibodyAnti-CMA1 antibodyAnti-CYH antibodyAnti-CYM antibody |
Information sourced from Uniprot.org