Anti-CLPX antibody (328-378 aa) (STJ194096)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CLPX at the amino acid range 328-378
General Information
| Short Description | Rabbit polyclonal anti-ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (328-378 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLPX |
| Gene ID | 10845 |
| Uniprot ID | CLPX_HUMAN |
| Immunogen | Synthesized peptide derived from the human CLPX at the amino acid range 328-378 |
| Immunogen Region | 328-378 aa |
| Specificity | This antibody detects endogenous levels of CLPX at Human/Mouse/Rat |
Additional Info
| Function | ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity. |
| Protein Name | Atp-Dependent Clpx-Like Chaperone - MitochondrialAtp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like - MitochondrialCaseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X |
| Database Links | Reactome: R-HSA-9837999 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Atp-Dependent Clpx-Like Chaperone - Mitochondrial antibodyAnti-Atp-Dependent Clp Protease Atp-Binding Subunit Clpx-Like - Mitochondrial antibodyAnti-Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit X antibodyAnti-CLPX antibody |
Information sourced from Uniprot.org