Anti-CLPTM1 antibody (200-249 aa) (STJ92345)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human CLPT1 at the amino acid range 200-249
General Information
| Short Description | Rabbit polyclonal anti-Putative lipid scramblase CLPTM1 (200-249 aa) for use in WB, IF and ELISA in Human, Mouse and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLPTM1 |
| Gene ID | 1209 |
| Uniprot ID | CLPT1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human CLPT1 at the amino acid range 200-249 |
| Immunogen Region | 200-249 aa |
| Specificity | CLPTM1 Polyclonal Antibody detects endogenous levels of CLPTM1 protein. |
Additional Info
| Function | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one. Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development. |
| Protein Name | Putative Lipid Scramblase Clptm1Cleft Lip And Palate Transmembrane Protein 1 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Putative Lipid Scramblase Clptm1 antibodyAnti-Cleft Lip And Palate Transmembrane Protein 1 antibodyAnti-CLPTM1 antibody |
Information sourced from Uniprot.org