| Short Description : | Rabbit polyclonal CLPTM1 (1-280) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLPTM1 |
| Gene ID: | 1209 |
| Uniprot ID: | CLPT1_HUMAN |
| Immunogen Region: | 1-280 |
| Immunogen Sequence: | MAAAQEADGARSAVVAAGGG SSGQVTSNGSIGRDPPAETQ PQNPPAQPAPNAWQVIKGVL FRIFIIWAISSWFRRGPAPQ DQAGPGGAPRVASRNLFPKD TLMNLHVYISEHEHFTDFNA TSALFWEQHDLVYGDWTSGE NSDGCYEHFAELDIPQSVQQ NGSIYIHVYFTKSGFHPDPR QKALYRRLATVHMSRMINKY KRRRFQKTKNLLTGETEADP EMIKRAEDYGPVEVISHWH |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CLPTM1 (NP_001285.1). |
| Tissue Specificity | Widely expressed. |
| Function | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one. Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development. |
| Protein Name | Putative Lipid Scramblase Clptm1Cleft Lip And Palate Transmembrane Protein 1 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Putative Lipid Scramblase Clptm1 antibodyAnti-Cleft Lip And Palate Transmembrane Protein 1 antibodyAnti-CLPTM1 antibody |
Information sourced from Uniprot.org
