| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mitochondrial Disaggregase (572-707) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLPB |
| Gene ID: |
81570 |
| Uniprot ID: |
CLPB_HUMAN |
| Immunogen Region: |
572-707 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 572-707 of human CLPB (NP_110440.1). |
| Immunogen Sequence: |
CHSELIQLVNKELNFWAKRA KQRHNITLLWDREVADVLVD GYNVHYGARSIKHEVERRVV NQLAAAYEQDLLPGGCTLRI TVEDSDKQLLKSPELPSPQA EKRLPKLRLEIIDKDSKTRR LDIRAPLHPEKVCNTI |
| Tissue Specificity | Widely expressed (at protein level). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes. |
| Post Translational Modifications | Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N-terminal autoinhibitory peptide. |
| Function | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. |
| Protein Name | Mitochondrial DisaggregaseSuppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form |
| Cellular Localisation | Mitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Mitochondrial Disaggregase antibodyAnti-Suppressor Of Potassium Transport Defect 3 Cleaved Into - Mitochondrial Disaggregase - Cleaved Form antibodyAnti-CLPB antibodyAnti-SKD3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
