| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Battenin (221-270 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLN3 |
| Gene ID: |
1201 |
| Uniprot ID: |
CLN3_HUMAN |
| Immunogen Region: |
221-270 aa |
| Specificity: |
CLN3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 221-270 |
| Post Translational Modifications | Highly glycosylated. Farnesylation is important for trafficking to lysosomes. Phosphorylated on both serine and threonine residues by PKA, PKG and CK2. |
| Function | Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission. Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing. Moreover regulates CTSD activity in response to osmotic stress. Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis. At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex. Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory. Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process. Participates also in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis. |
| Protein Name | BatteninBatten Disease ProteinProtein Cln3 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinLate EndosomeLysosomeGolgi ApparatusGolgi Apparatus MembraneGolgi StackTrans-Golgi NetworkCell MembraneRecycling EndosomeMembrane RaftMembraneCaveolaEarly Endosome MembraneSynapseSynaptosomeLate Endosome MembraneCytoplasmic VesicleAutophagosomeCln3 Is Not Present In Late Endosomes/Lysosomes In Fibroblasts And NeuronsTrafficks From Cell Membrane To Golgi Via EndosomesOsmotic Stress Changes The Subcellular Localization Of Cln3Trafficks To Intracellular Compartments Via The Plasma Membranet Through Ap3m1-Dependent MechanismsExcluded From The Synaptic Vesicles |
| Alternative Antibody Names | Anti-Battenin antibodyAnti-Batten Disease Protein antibodyAnti-Protein Cln3 antibodyAnti-CLN3 antibodyAnti-BTS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
