| Short Description : | Rabbit polyclonal anti-Dual specificity protein kinase CLK4 (101-150 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLK4 |
| Gene ID: | 57396 |
| Uniprot ID: | CLK4_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CLK4 at the amino acid range 101-150 |
| Immunogen Region: | 101-150 aa |
| Specificity: | CLK4 Polyclonal Antibody detects endogenous levels of CLK4 protein. |
| Post Translational Modifications | Autophosphorylates on all three types of residues. |
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| Protein Name | Dual Specificity Protein Kinase Clk4Cdc-Like Kinase 4 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Clk4 antibodyAnti-Cdc-Like Kinase 4 antibodyAnti-CLK4 antibody |
Information sourced from Uniprot.org
