| Post Translational Modifications | Autophosphorylates on all three types of residues. |
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| Protein Name | Dual Specificity Protein Kinase Clk3Cdc-Like Kinase 3 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmCytoplasmic VesicleSecretory VesicleAcrosomeIsoform 2: Nucleus SpeckleCo-Localizes With Serine- And Arginine-Rich (Sr) Proteins In The Nuclear Speckles |
| Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Clk3 antibodyAnti-Cdc-Like Kinase 3 antibodyAnti-CLK3 antibody |
Information sourced from Uniprot.org
