| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Chloride intracellular channel protein 6 (411-460 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CLIC6 |
| Gene ID: | 54102 |
| Uniprot ID: | CLIC6_HUMAN |
| Immunogen Region: | 411-460 aa |
| Specificity: | CLIC6 Polyclonal Antibody detects endogenous levels of CLIC6 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CLIC6 at the amino acid range 411-460 |
| Post Translational Modifications | Phosphorylated. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport. |
| Protein Name | Chloride Intracellular Channel Protein 6Glutaredoxin-Like Oxidoreductase Clic6Parchorin |
| Cellular Localisation | CytoplasmCell MembraneSingle-Pass Membrane ProteinPredominantly CytoplasmicUpon Chloride Ion Efflux From The CellIt Is Translocated To The Plasma Membrane |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 6 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic6 antibodyAnti-Parchorin antibodyAnti-CLIC6 antibodyAnti-CLIC1L antibody |
Information sourced from Uniprot.org