Anti-CLIC4 antibody [R02-7A1] (STJA0034180)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human CLIC4
General Information
| Short Description | Rabbit monoclonal anti-CLIC4 for use in WB, IHC-F, IHC-P, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-7A1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CLIC4 |
| Gene ID | 25932 |
| Uniprot ID | CLIC4_HUMAN |
| Immunogen | A synthetic peptide of human CLIC4 |
Additional Info
| Tissue Specificity | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. |
| Protein Name | Chloride Intracellular Channel Protein 4Glutaredoxin-Like Oxidoreductase Clic4Intracellular Chloride Ion Channel Protein P64h1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmic Vesicle MembraneSingle-Pass Membrane ProteinNucleusCell MembraneMitochondrionCell JunctionEndoplasmic Reticulum MembraneColocalized With Akap9 At The Centrosome And MidbodyExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainPresent In An Intracellular Vesicular Compartment That Likely Represent Trans-Golgi Network VesiclesMight Not Be Present In The Nucleus Of Cardiac Cells |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 4 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic4 antibodyAnti-Intracellular Chloride Ion Channel Protein P64h1 antibodyAnti-CLIC4 antibody |
Information sourced from Uniprot.org